The association of vitamins C and K₃ kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy

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• 作者：Verrax ; Julien ; Cadrobbi ; Julie ; Delvaux ; Marianne ; Jamison ; James M. ; Gilloteaux ; Jacques ; et. al.
• 关键词：Autoschizis ; Oxidative stress ; Vitamins C and K₃ ; Cancer ; TLT ; transplantable liver tumour ; NF-κ ; B ; nuclear factor kappa B ; GSH ; reduced glutathione ; LDH ; lactate deshydrogenase
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2003
• 出版时间：May, 2003
• 年：2003
• 卷：38
• 期：5
• 页码：451-457
• 全文大小：468 K

文摘

Deficiency of alkaline and acid DNase is a hallmark in all non-necrotic cancer cells in animals and humans. These enzymes are reactivated at early stages of cancer cell death by vitamin C (acid DNase) and vitamin K₃ (alkaline DNase). Moreover, the coadministration of these vitamins (in a ratio of 100:1, for C and K₃, respectively) produced selective cancer cell death. Detailed morphological studies indicated that cell death is produced mainly by autoschizis, a new type of cancer cell death. Several mechanisms are involved in such a cell death induced by CK₃, they included: formation of H₂O₂ during vitamins redox cycling, oxidative stress, DNA fragmentation, no caspase-3 activation, and cell membrane injury with progressive loss of organelle-free cytoplasm. Changes in the phosphorylation level of some critical proteins leading to inactivation of NF-κB appear as main intracellular signal transduction pathways. The increase knowledge in the mechanisms underlying cancer cells death by CK₃ may ameliorate the techniques of their in vivo administration. The aim is to prepare the introduction of the association of vitamins C and K₃ into human clinics as a new, non-toxic adjuvant cancer therapy.