Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation
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- 作者：M.C. Krawczyka ; N. Navarroa ; M.G. Blakeb ; A. Romanoc ; M. Feldc ; 1 ; mfeld@fbmc.fcen.uba.ar" class="auth_mail" title="E-mail the corresponding author ; M.M. Bocciaa ; 1 ; mboccia@ffyb.uba.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：dHIP ; dorsal hippocampus ; ERK/MAPK ; extracellular-signal regulated kinase/mitogen-activated protein kinase (also known as p42/p44MAPK) ; HFS ; high footshock-trained animals ; HIP ; hippocampus ; IA ; inhibitory avoidance task ; LFS ; low footshock-trained animals ; LTM ; long-term memory ; N ; nä ; ive animals ; NF-κB ; Rel/Nuclear factor-κB ; NR ; non-reactivated animals ; PD ; PD098059 (a MEK1/2 inhibitor) ; pERK ; phosphorylated ERK ; p-LTM ; persistent long-term memory ; R ; reactivated animals ; SDS-PAGE ; Sodium
- 刊名：Neurobiology of Learning and Memory
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：133
- 期：Complete
- 页码：79-88
- 全文大小：1232 K
文摘
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Weak and strong IA memory retrieval induce differential hippocampal ERK1/2 activity.
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Post-retrieval dHIP ERK2 inhibition impairs memory reconsolidation tested at 24 h.
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dHIP ERK inhibition 3 h after retrieval impairs persistent-LTM at 7 days.
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dHIP ERK inhibition effect on persistent-LTM is retrieval-dependent/retrieval-induced.