Crossed cerebellar diaschisis after stroke identified noninvasively with cerebral blood flow-weighted arterial spin labeling MRI

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• 作者：Megan K. Strother^a ; Cari Buckingham^a ; Carlos C. Faraco^a ; Daniel F. Arteaga^a ; Pengcheng Lu^b ; Yaomin Xu^b ; Manus J. Donahue^a ; ^{mj.donahue@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Crossed cerebellar diaschisis ; BOLD ; fMRI ; Cerebrovascular reactivity ; CBF ; Wallerian degeneration
• 刊名：European Journal of Radiology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：85
• 期：1
• 页码：136-142
• 全文大小：1350 K

文摘

Crossed cerebellar diaschisis (CCD) is most commonly investigated using hemodynamic PET and SPECT imaging. However, noninvasive MRI offers advantages of improved spatial resolution, allowing hemodynamic changes to be compared directly with structural findings and without concerns related to ionizing radiation exposure. The aim of this study was to evaluate relationships between CCD identified from cerebral blood flow (CBF)-weighted arterial spin labeling (ASL) MRI with cerebrovascular reactivity (CVR)-weighted blood oxygenation level dependent (BOLD) MRI, Wallerian degeneration, clinical motor impairment, and corticospinal tract involvement.

Methods

Subjects (n = 74) enrolled in an ongoing observational stroke trial underwent CBF-weighted ASL and hypercapnic CVR-weighted BOLD MRI. Hemispheric asymmetry indices for basal cerebellar CBF, cerebellar CVR, and cerebral peduncular area were compared between subjects with unilateral supratentorial infarcts (n = 18) and control subjects without infarcts (n = 16). CCD required (1) supratentorial infarct and (2) asymmetric cerebellar CBF (>95% confidence interval relative to controls).

Results

In CCD subjects (n = 9), CVR (p = 0.04) and cerebral peduncular area (p < 0.01) were significantly asymmetric compared to controls. Compared to infarct subjects not meeting CCD criteria (n = 9), CCD subjects had no difference in corticospinal tract location for infarct (p = 1.0) or motor impairment (p = 0.08).

Conclusions

CCD correlated with cerebellar CVR asymmetry and Wallerian degeneration. These findings suggest that noninvasive MRI may be a useful alternative to PET or SPECT to study structural correlates and clinical consequences of CCD following supratentorial stroke.