Nerve growth factor & TrkA as novel therapeutic targets in cancer
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- 作者：Ihsan Ekin Demir ; ekin.demir@tum.de" class="auth_mail" title="E-mail the corresponding author ; Elke Tieftrunk ; Stephan Schorn ; Helmut Friess ; Gü ; ralp O. Ceyhan
- 关键词：NGF ; TrkA ; p75NTR ; Cancer ; Growth ; Pain ; Gene fusion ; Gene rearrangement ; Monoclonal antibodies ; Microenvironment ; Nerves ; Therapeutic target
- 刊名：Biochimica et Biophysica Acta (BBA)-Reviews on Cancer
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1866
- 期：1
- 页码：37-50
- 全文大小：1325 K
文摘
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Most human cancers overexpress NGF and/or its receptors (TrkA/p75NTR).
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Genetic TrkA rearrangements mediate overactive TrkA signaling in cancer.
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NGF/TrkA/p75NTR are highly promising, novel targets for cancer- and pain treatment.