Increase HDL-C level over the menopausal transition is associated with greater atherosclerotic progression
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Higher HDL-C may not necessarily cardioprotective over the menopausal transition.

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Premenopausal higher level of HDL-C was associated with less atherosclerosis.

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Increasing HDL-C over menopause was associated with more atherosclerosis.

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The quality of HDL may be altered over the menopausal transition.

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