3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors
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- 作者：An T. Vu ; Stephen T. Cohn ; Eugene A. Terefenko ; William J. Moore ; Puwen Zhang ; Paige E. Mahaney ; Eugene J. Trybulski ; Igor Goljer ; Rebecca Dooley ; Jenifer A. Bray ; Grace H. Johnston ; Jennifer Leiter
- 关键词：3-(Arylamino)-3-phenylpropan-2-olamines ; Serotonin and norepinephrine reuptake inhibitors ; SNRI ; Norepinephrine reuptake inhibitors ; NRI ; Serotonin reuptake inhibitor ; SRI ; Monoamine reuptake inhibitors
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2009
- 出版时间：1 May 2009
- 年：2009
- 卷：19
- 期：9
- 页码：2464-2467
- 全文大小：391 K
文摘
A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the dopamine transporter.