Efficient syntheses of 1,2,3,4,4a,5-hexahydro-pyrazino[2,1-c][1,4]benzothiazine-6,6-dioxide

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• 作者：Ronald C. Bernotas ; Rebecca J. Dooley
• 关键词：Arylpiperazine ; Cascade reaction ; Sulfones ; Aromatic substitution
• 刊名：Tetrahedron
• 出版年：2010
• 出版时间：27 March 2010
• 年：2010
• 卷：66
• 期：13
• 页码：2273-2276
• 全文大小：206 K

文摘

Expeditious routes to 1,2,3,4,4a,5-hexahydro-pyrazino[2,1-c][1,4]benzothiazine-6,6-dioxide, a methylenesulfone-constrained arylpiperazine, have been developed. The key step forms the tricyclic system in a cascade of reactions via a 1,4-addition, nitrogen alkylation, and aromatic substitution sequence.