Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development
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- 作者：Amanda N. Marra ; Rebecca A. Wingert ; rwingert@nd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：C ; cloaca ; CAKUT ; congenital and acquired diseases of the urinary tract ; cetn4 ; centrin 4 ; cRNA ; capped RNA ; CS ; corpuscle of Stannius ; DAPT ; N-[N-(3 ; 5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester ; DE ; distal early ; DEAB ; 4-diethylaminobenzaldehyde ; DL ; distal late ; ETS ; E26 transformation-specific ; etv4 ; ets variant 4 ; etv5a ; ets variant 5a ; etv5b ; ets variant 5b ; FISH ; fluorescent in situ hybridization ; hpf ; hours post fertilization ; IF ; immunofluorescence ; IM ; intermediate meso
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：411
- 期：2
- 页码：231-245
- 全文大小：9368 K
文摘
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Zebrafish renal progenitors show regionalized etv5a expression in MCC precursors.
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etv5a deficiency reduces MCC number and is rescued by etv5a overexpression 93.
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etv4 deficiency reduces MCC number and etv5a/4 dramatically reduces MCCs.
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Retinoic acid signaling positively regulates etv5a expression during MCC formation.
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Notch signaling negatively regulates etv5a expression during MCC formation.