Sex-related differences in the skeletal phenotype of aged vitamin D receptor global knockout mice

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• 作者：Jackson W. Ryan^a ; ^b ; ^c ; Yolandi Starczak^a ; ^b ; ^c ; Helen Tsangari^a ; ^b ; ^c ; Rebecca K. Sawyer^a ; ^b ; ^c ; Rachel A. Davey^a ; ^b ; ^c ; Gerald J. Atkins^a ; ^b ; ^c ; Howard A. Morris^a ; ^b ; ^c ; ¹ ; ^{howard.morris@unisa.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Paul H. Anderson^a ; ^b ; ^c ; ¹
• 关键词：Vitamin D receptor ; 1 ; 25-Dihydroxyvitamin D3 ; Osteoblasts ; Osteoclasts ; Bone remodelling
• 刊名：Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：164
• 期：Complete
• 页码：361-368
• 全文大小：1652 K

文摘

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d="par0005">Adult male Vdr^−/− mice exhibit bone loss despite being fed the rescue diet.

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d="par0010">Female Vdr^−/− mice exhibit vertebral bone loss and yet increased femoral bone volume.

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d="par0015">Rescue diet fed to Vdr^−/− mice does not normalise bone volume.

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d="par0020">In addition to the intestine, VDR may be required to directly regulate bone homeostasis.

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