A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

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• 作者：Meromit Singer¹ ; ⁶ ; Chao Wang² ; ⁶ ; Le Cong¹ ; Nemanja D. Marjanovic¹ ; ³ ; Monika S. Kowalczyk¹ ; Huiyuan Zhang² ; Jackson Nyman¹ ; Kaori Sakuishi² ; Sema Kurtulus² ; David Gennert¹ ; Junrong Xia² ; John Y.H. Kwon¹ ; James Nevin² ; Rebecca H. Herbst¹ ; Itai Yanai⁴ ; Orit Rozenblatt-Rosen¹ ; Vijay K. Kuchroo² ; ^{vkuchroo@evergrande.hms.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Aviv Regev¹ ; ³ ; ⁵ ; ^{aregev@broadinstitute.org" class="auth_mail" title="E-mail the corresponding author} ; Ana C. Anderson² ; ⁷ ; ^{acanderson@partners.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CD8 ; T cell ; exhaustion ; dysfunction ; cancer ; single-cell ; CRISPR/Cas9 ; Gata-3 ; metallothioneins ; zinc ; TILs ; tumor
• 刊名：Cell
• 出版年：2016
• 出版时间：8 September 2016
• 年：2016
• 卷：166
• 期：6
• 页码：1500-1511.e9
• 全文大小：3135 K

文摘

<dl class="listitem" id="list_ulist0010"><dt class="label">•dt><dd>

d="p0010">Distinct gene modules for T cell dysfunction and activation can be uncoupled

dd><dt class="label">•dt><dd>

d="p0015">Single-cell profiling of CD8 TILs shows that these modules are exclusive

dd><dt class="label">•dt><dd>

d="p0020">Metallothioneins, zinc regulators, promote T cell dysfunction

dd><dt class="label">•dt><dd>

d="p0025">CRISPR-Cas9 targeting shows Gata-3, a zinc-finger TF, promotes dysfunction

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