The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson壮s disease therapy
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- 作者：Carol A. Lazzaraa ; Rebeccah R. Rileyb ; Anand Raneb ; Julie K. Andersenb ; jandersen@buckinstitute.org" class="auth_mail" title="E-mail the corresponding author ; Yong-Hwan Kima ; yhkim@desu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Combination therapy ; MPTP ; Neurodegenerative disease ; Calpain 1 ; AIM
- 刊名：Brain Research
- 出版年：2015
- 出版时间：5 October 2015
- 年：2015
- 卷：1622
- 期：Complete
- 页码：127-136
- 全文大小：3073 K
文摘
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Lithium reduces MPTP-induced abnormal involuntary movements (AIMs) in a mouse model.
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Lithium壮s effect is mediated by calpain 1 inhibition.
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Lithium increases the HAT activity and tyrosine hydroxylase expression.
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Combining lithium with l-Dopa/Carbidopa may be a viable option for PD.