Identification of β-hematin inhibitors in the MMV Malaria Box
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- 作者：Kim Y. Fong1 ; kim.y.fong@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Rebecca D. Sandlin1 ; rdsandlin@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; David W. Wright ; david.wright@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antimalarial ; Hemozoin ; β-hematin ; Biomineralization ; Plasmodium falciparum ; MMV Malaria Box
- 刊名：International Journal for Parasitology: Drugs and Drug Resistance
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：5
- 期：3
- 页码：84-91
- 全文大小：1706 K
文摘
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Ten of 400 Malaria Box compounds were found to be potent β-hematin inhibitors.
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We confirmed similar in vitro antimalarial activity to results from previous screens.
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7 of the 9 commercially available hits were validated hemozoin inhibitors in culture.