Electronic MEMS for triggered delivery

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• 作者：Richards Grayson ; Amy C. ; Scheidt Shawgo ; Rebecca ; Li ; Yawen ; Cima ; Michael J.
• 关键词：MEMS ; BioMEMS ; Implant ; Implantable ; Electronic ; Drug delivery ; Triggered ; Microchip
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2004
• 出版时间：February 10, 2004
• 年：2004
• 卷：56
• 期：2
• 页码：173-184
• 全文大小：168 K

文摘

Implantable electronic devices such as pacemakers and neural implants are often used for electrical stimulation. The usage of microfabrication techniques to produce microelectromechanical systems (MEMS) has allowed engineers to address a wider range of clinical indications. A new direction in the area of MEMS technology is the goal of achieving pulsatile drug delivery. The digital capabilities of MEMS may allow greater temporal control over drug release compared to traditional polymer-based systems, while the batch-processing techniques used in the microelectronics industry can lead to greater device uniformity and reproducibility than is currently available to the pharmaceutical industry. A repertoire of structures, including microreservoirs, micropumps, valves, and sensors, is being developed that will provide a strong foundation for the design of integrated, responsive MEMS for drug delivery.