Health care resource use, productivity, and costs among patients with moderate to severe plaque psoriasis in the United States

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• 作者：Caroline P. Schaefer ; MBA^a ; ^{caroline.schaefer@covance.com" class="auth_mail" title="E-mail the corresponding author} ; Joseph C. Cappelleri ; PhD^c ; Rebecca Cheng ; PharmD ; MS^b ; Jason C. Cole ; PhD^b ; Scott Guenthner ; MD^d ; Joseph Fowler ; MD^e ; Sandy Johnson ; MD^f ; Carla Mamolo ; PhD^c
• 关键词：burden of illness ; chart review ; costs ; economic burden ; health care resource use ; moderate to severe plaque psoriasis ; observational research ; productivity
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：73
• 期：4
• 页码：585-593.e3
• 全文大小：649 K

文摘

Comprehensive studies on costs of moderate to severe plaque psoriasis (MSPP) have not been conducted in the United States.

Objective

We sought to evaluate current health care resource use, productivity, and costs among patients with MSPP in routine practice.

Methods

A total of 200 adults seeking MSPP treatment enrolled in 9 US sites. Consented patients reported symptoms, treatment, lost productivity, and costs; 6-month retrospective chart review captured health care resource use and clinical characteristics. Costs were assigned to health care resource use and lost productivity using standard algorithms. Differences by Psoriasis Area and Severity Index (PASI) group, based on PASI score (≤10, >10-≤20, >20) at enrollment, were evaluated. Analyses included descriptive statistics and analysis of variance or Kruskal-Wallis tests.

Results

Most patients (79.5%) were prescribed 1 or more MSPP medications (mean: 1.5); 36.0% and 9.0% received self-administered biologics and systemic therapies, respectively. Mean number of nonprescription treatments was 12.3. Differences by PASI group were observed for overall work and activity impairment (P < .02). Six-month total MSPP direct costs per patient were $11,291; indirect costs were $2101 and differed across PASI groups (P = .0008).

Limitations

This study enrolled patients with MSPP actively seeking care.

Conclusion

Despite treatment, a number of patients with MSPP continue to experience moderate to severe PASI scores, impaired functioning, and high costs suggesting a need for new treatment options.