Lipotoxicity and the Development of Heart Failure: Moving from Mouse to Man

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• 作者：William C. Stanley ; Fabio A. Recchia
• 刊名：Cell Metabolism
• 出版年：2010
• 出版时间：1 December 2010
• 年：2010
• 卷：12
• 期：6
• 页码：555-556
• 全文大小：266 K

文摘

Intracardiac lipid accumulation can cause heart failure. A study in Journal of Clinical Investigation (Son et al., 2010) found that cardiac-specific PPARγ overexpression caused heart failure with intracardiac triglyceride accumulation. Overexpressing PPARγ on a PPARα−/− background improved cardiac function, suggesting that specific lipid metabolites and lipid packaging determine cardiac lipotoxicity.