Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice
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- 作者：Tatyana Strekalovaa ; t.strekalova@maastrichtuniversity.nl" class="auth_mail" title="E-mail the corresponding author ; Joã ; o P. Costa-Nunesa ; b ; Ekaterina Veniaminovaa ; c ; Aslan Kubatievc ; Klaus-Peter Lescha ; d ; Vladimir P. Chekhonine ; Matthew C. Evansf ; Harry W.M. Steinbuscha
- 关键词：Western diet ; Depression ; Anxiety ; Insulin receptor sensitizers ; Toll-like receptor four (Tlr4) ; Mice
- 刊名：Journal of Affective Disorders
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：196
- 期：Complete
- 页码：109-116
- 全文大小：1657 K
文摘
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Insulin receptor sensitizer dicholine succinate reduces the effects of cholesterol.
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These effects in mice concern altered anxiety- and depressive-like behaviors.
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Dicholine succinate normalizes brain and liver Tlr4 and PPARGC1b.
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Liver dystrophy and lipid accumulation are not prevented by dicholine succinate.
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Dicholine succinate may activate mitochondrial and anti-inflammatory mechanisms.