Il17a and Il17rc are expressed by sputum and blood neutrophils in cystic fibrosis.
Neutrophil Il17a and Il17rc expression is associated with pulmonary exacerbation.
Sputum elastase and MMP9 activity correlates with %IL-17 + ve neutrophils.
BAL neutrophils from cystic fibrosis mice express Il17a.
Neutrophil Il17rc expression is IL-23 – dependent.