Opposite effects of mu and delta opioid receptor agonists on excitatory propagation induced in rat somatosensory and insular cortices by dental pulp stimulation
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- 作者：Eiko Yokotaa ; b ; Yuko Koyanagib ; c ; Hiroko Nakamuraa ; d ; Eri Horinukia ; e ; Yoshiyuki Oib ; c ; Masayuki Kobayashia ; f ; g ; kobayashi.masayuki@nihon-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：DAMGO ; [D-Ala2 ; N-MePhe4 ; Gly5-ol]-enkephalin ; DOR ; delta opioid receptor ; DPDPE ; [D-Pen2 ; 5]-enkephalin ; IC ; insular cortex ; IOR ; insular oral region ; KOR ; kappa opioid receptor ; MCA ; middle cerebral artery ; MOR ; mu opioid receptor ; Pyr ; pyramidal cells ; S1 ; primary somatosensory cortex ; S2 ; secondary somatosensory cortex
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：628
- 期：Complete
- 页码：52-58
- 全文大小：1947 K
文摘
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Opioidergic effect on cortical excitatory propagation was studied by optical imaging.
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Excitatory propagation was elicited by electrical stimulation of upper molar pulp.
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Molar pulp stimulation induced excitation in the somatosensory and insular cortices.
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Mu and delta receptor agonists suppressed and enhanced the excitation, respectively.