Modulation of serotonin transporter function by kappa-opioid receptor ligands

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• 作者：Santhanalakshmi Sundaramurthy^a ; Balasubramaniam Annamalai^b ; Devadoss J. Samuvel^c ; Toni S. Shippenberg^d ; Lankupalle D. Jayanthi^a ; Sammanda Ramamoorthy^a ; ^{sammanda.ramamoorthy@vcuhealth.org}
• 关键词：Kappa opioid receptor ; Serotonin ; Clearance ; Serotonin transporter ; Phosphorylation ; Trafficking
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：281-292
• 全文大小：1612 K
• 卷排序：113

文摘

K-opioid receptor agonists produce conditional aversive and pro-depressant-like effects. SERT is one of the major determinants of synaptic 5-HT and serotonergic neurotransmission. K-opioid receptor activation decreases 5-HT uptake through Akt and CaMKII pathways. K-opioid receptor activation decreases surface SERT, increases phosphorylation and endocytosis. K-opioid receptor activation decreases serotonin clearance in the striatum.