Chemokine receptor internalization and intracellular trafficking

详细信息    查看全文

• 作者：Nicole F. Neel ; Evemie Schutyser ; Jiqing Sai ; Guo-Huang Fan and Ann Richmond
• 关键词：Chemokine receptor ; Internalization ; Trafficking ; Endocytosis ; Modifications
• 刊名：Cytokine and Growth Factor Reviews
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：16
• 期：6
• 页码：637-658
• 全文大小：418 K

文摘

The internalization and intracellular trafficking of chemokine receptors have important implications for the cellular responses elicited by chemokine receptors. The major pathway by which chemokine receptors internalize is the clathrin-mediated pathway, but some receptors may utilize lipid rafts/caveolae-dependent internalization routes. This review discusses the current knowledge and controversies regarding these two different routes of endocytosis. The functional consequences of internalization and the regulation of chemokine receptor recycling will also be addressed. Modifications of chemokine receptors, such as palmitoylation, ubiquitination, glycosylation, and sulfation, may also impact trafficking, chemotaxis and signaling. Finally, this review will cover the internalization and trafficking of viral and decoy chemokine receptors.