Glucose-dependent insulinotropic polypeptide (GIP) and GIP receptor (GIPR) genes: An association analysis of polymorphisms and bone in young and elderly women
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- 作者：Gaurav Garga ; b ; 1 ; Fiona E. McGuigana ; b ; 1 ; Jitender Kumarc ; Holger Luthmanf ; Valeriya Lyssenkod ; e ; Kristina Akessona ; b ; kristina.akesson@med.lu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：GIP ; GIPR ; Polymorphism ; BMD ; Fat mass ; Serum GIP
- 刊名：Bone Reports
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：4
- 期：Complete
- 页码：23-27
- 全文大小：244 K
文摘
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We analyzed polymorphisms (SNPs) in the glucose-dependent insulinotropic polypeptide (GIP) and GIP receptor (GIPR) genes
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Bone phenotypes included BMD, BMC, bone microarchitecture, fracture and in addition, serum GIP
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two cohorts of women were investgated: OPRA (all women aged 75y, n=1044) and PEAK-25 (all women aged 25y; n=1061)
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GIPR genotype was associated with lower ultrasound values in young women
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GIP genotype was associated with lower ultrasound and femoral neck BMD and BMC in the elderly