SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner
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- 作者：Alena Há ; jková ; a ; &Scaron ; á ; rka Techlovská ; a ; Michaela Dvořá ; ková ; a ; Jayne Nicole Chambersa ; Jiří ; Kumpo&scaron ; ta ; Pavla Hubá ; lková ; a ; Laurent Prezeaub ; Jaroslav Blahosa ; blahos@img.cas.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Seven transmembrane receptors ; G-protein coupled receptors ; Cannabinoid receptor 1 ; Protein-protein interactions ; Bias signaling ; Receptor endocytosis
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：201-214
- 全文大小：3051 K
文摘
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We detected SGIP1 as a novel interacting partner of CB1R.
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SGIP1 interferes with endocytosis of the activated CB1R and stabilizes it on the cell surface.
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β-arrestin2 association with activated CB1R is enhanced by SGIP1.
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Certain G-protein signaling activated by CB1R is unaffected by SGIP1, but ERK1/2 pathway is negatively regulated by SGIP1.
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SGIP1 regulates CB1R signaling in a biased manner.