Protective effects of the polyphenols (+)-episesamin and sesamin against PDGF-BB-induced activation of vascular smooth muscle cells are mediated by induction of haem oxygenase-1 and inhibition of mitogenic signalling
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- 作者：Christian Freise ; christian.freise@charite.de" class="auth_mail" title="E-mail the corresponding author ; Kerstin Sommer ; Uwe Querfeld
- 关键词：[Ca]i ; intracellular calcium levels ; ES ; (+)-episesamin ; HO-1 ; haem oxygenase-1 ; MAPK ; mitogen-activated protein kinase ; MMP ; matrix-metalloproteinase ; NF-魏B ; nuclear factor-kappa B ; PDGF ; platelet-derived growth factor ; PDGFR伪 ; platelet-derived growth factor receptor alpha ; PI3K ; phosphatidylinositol-3-OH-kinase ; ROS ; reactive oxygen species ; SE ; sesamin ; TNF-伪 ; tumour necrosis factor alpha ; VSMC ; vascular smooth muscle cell ; ZnPP IX ; zinc protoporphyrin IX
- 刊名：Journal of Functional Foods
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：18
- 期：part_PA
- 页码：586-597
- 全文大小：1829 K
文摘
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The polyphenols (+)-episesamin and sesamin block PDGF-BB-induced activation of VSMC.
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Targets are PDGF-induced MAPK and PI3K signalling and the activation of NF-魏B.
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(+)-episesamin and sesamin induce protein expression of haem oxygenase-1 (HO-1).
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Both polyphenols attenuate the PDGF-BB-induced secretion of MMP-2 and MMP-9.
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Both polyphenols show potential beneficial activity against PDGF-BB-induced atherosclerosis.