t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions
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- 作者：Roxann Freemana ; 1 ; Be壮eri Niegoa ; 1 ; David R. Croucherb ; 2 ; Lars O. Pedersenc ; Robert L. Medcalfa ; Robert.medcalf@monash.edu" class="auth_mail
- 关键词：BBB ; blood-brain barrier ; CNBr-fgn ; cyanogen bromide-digested fibrinogen ; FITC ; fluorescein isothiocyanate ; ICH ; intracerebral haemorrhage ; OGD ; oxygen-glucose deprivation ; LDLR ; low density lipoprotein receptor ; LRP-1 ; LDLR-related protein 1 ; PFA ; paraformaldehyde ; ROCK ; Rho-kinase ; TJ ; tight-junction ; t-PA ; tissue-type plasminogen activator ; ZO-1 ; zonula occludens 1
- 刊名：Brain Research
- 出版年：27 May 2014
- 年：2014
- 卷：1565
- 期：Complete
- 页码：63-73
- 全文大小：4515 K
文摘
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t-PA but not desmoteplase increases blood-brain barrier (BBB) permeability in vitro.
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Ischaemic conditions attenuate the action of t-PA on BBB permeability.
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The increase in BBB permeability by t-PA is reversible only within 2 h of onset.
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t-PA and desmoteplase bind to LRP-1 with similar affinity.
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Desmoteplase does not antagonise the ability of t-PA to increase permeability.