Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice
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- 作者：Subhayan Sura ; subhayansur18@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Debolina Pala ; Rituparna Roya ; Atish Baruaa ; Anup Royb ; Prosenjit Sahaa ; Chinmay Kumar Pandaa ; ckpanda.cnci@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：EGCG ; epigallocatechin gallate ; TF ; theaflavine ; NDEA ; N-nitrosodiethylamine ; CD44 ; cluster of differentiation 44 ; sFRP1 ; secreted frizzled-related protein 1 ; APC ; adenomatosis polyposis coli ; Hh ; hedgehog pathway ; Gli1 ; glioma-associated oncogene homolog 1 ; SMO ; smoothened homolog (Drosophila) ; EGFR ; epidermal growth factor receptor
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：300
- 期：Complete
- 页码：34-46
- 全文大小：3890 K
文摘
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Simultaneous tongue and liver carcinogenesis in mice by oral NDEA administration
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10">Restriction of both carcinogenesis by EGCG and TF at early pre-malignant stages
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15">The mechanisms of carcinogenesis and restriction were similar in both the organs.
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Changes in proliferation/apoptosis and CD44 + ve population were seen in the events.
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The self renewal Wnt and Hedgehog pathways were modulated during the restriction.