Involvement of presynaptic 5-HT_1A receptors in the low propensity of brexpiprazole to induce extrapyramidal side effects in rats

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• 作者：Cedric Mombereau^a ; ^{CMOM@lundbeck.com} ; Jø ; rn Arnt^b ; Arne Mø ; rk^a
• 关键词：ANOVA ; Analysis of variance ; DA ; Dopamine ; EPS ; Extrapyramidal side effects ; l-DOPA ; l-3 ; 4-dihydroxyphenylalanine ; mPFC ; Medial prefrontal cortex ; 5-HT ; Serotonin
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：153
• 期：Complete
• 页码：141-146
• 全文大小：545 K
• 卷排序：153

文摘

Brexpiprazole has low cataleptogenic activity due to balanced 5-HT1A/D2 activity. Dialysis proposes preferential brexpiprazole effect on presynaptic 5-HT1A receptors. Aripiprazole has low cataleptogenic activity, primarily driven by D2 agonism. 5-HT1A agonists reverse catalepsy by preferential effect on presynaptic receptors.