Roles of the serotonin 5-HT4 receptor in dendrite formation of the rat hippocampal neurons in vitro

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• 作者：Naoki Kozono^a ; Akiko Ohtani^a ; Takashi Shiga^a ; ^b ; ^{tshiga@md.tsukuba.ac.jp}
• 关键词：Serotonin ; Dendrite formation ; Hippocampus ; Serotonin 4 receptor ; Dissociated cell culture
• 刊名：Brain Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：1655
• 期：Complete
• 页码：114-121
• 全文大小：1040 K
• 卷排序：1655

文摘

5-HT1A agonist inhibited dendrite formation of cultured hippocampal neurons. 5-HT4 agonist promoted dendrite formation of cultured hippocampal neurons. PKA inhibitor neutralized the effects of 5-HT4 agonist on dendrite formation. 5-HT4 agonist increased the expression of BDNF mRNA. TrkB antagonist neutralized the effects of 5-HT4 agonist on dendrite formation.