The 5-HT6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus
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- 作者：Kjartan F. Herrika ; kfh@lundbeck.com" class="auth_mail" title="E-mail the corresponding author ; Arne Mø ; rka ; arm@lundbeck.com" class="auth_mail" title="E-mail the corresponding author ; Nelly Richarda ; nelly-richard@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Christoffer Bundgaardb ; cbun@lundbeck.com" class="auth_mail" title="E-mail the corresponding author ; Jesper F. Bastlunda ; jfb@lundbeck.com" class="auth_mail" title="E-mail the corresponding author ; Inge E.M. de Jongc ; idj@lundbeck.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT6 receptor ; Idalopirdine ; Donepezil ; Neuronal oscillations ; Acetylcholine ; Alzheimer's disease
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：351-363
- 全文大小：2215 K
文摘
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Idalopirdine augments the effects of donepezil on hippocampal neuronal oscillations.
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5">Idalopirdine augments the effect of donepezil on acetylcholine in the hippocampus.
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5-HT6R antagonism augments effects of cholinesterase inhibition in the hippocampus.
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5">Idalopirdine potentiates the effects of donepezil on biomarkers for cognition.