Proinflammatory cytokine and cytokine receptor gene expression kinetics following challenge with Flavobacterium psychrophilum in resistant and susceptible lines of rainbow trout (Oncorhynchus mykiss)
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- 作者：Ivan Kutyreva ; b ; ivan.kutyrev@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Beth Clevelanda ; Timothy Leedsa ; Gregory D. Wiensa ; greg.wiens@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Flavobacterium psychrophilum ; Bacterial cold water disease ; Genetic resistance ; Selective breeding ; Proinflammatory cytokines ; Cytokine receptors
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：542-553
- 全文大小：1802 K
文摘
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Multiplex RT-PCR assay developed that measures proinflammatory gene expression.
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Fp challenge increased expression of cytokines tnfa1, tnfa2, tnfa3, il1b1, il1b2, and il11a.
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Fp challenge increased expression of putative receptors il1r1-like-b, il1r2, tnfrsf1a, tnfrsf1a-like-b and tnfrsf9.
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Fp challenge decreased expression of il1r-like-1 and tnfrsf1a-like-a genes.
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Cytokine receptor gene expression differentiated between genetic lines of rainbow trout.