Membrane receptor cross talk in gonadotropin-, IGF-I-, and insulin-mediated steroidogenesis in fish ovary: An overview
文摘
Gonadotropin regulation of fish ovarian steroidogenesis mediated through GPCR revealed interactions of cAMP, calmodulin, CaMKs and MAP kinase pathways. Gonadotropin in fish ovary trans-activate membrane-bound EGFR and activate ERK1/2 signaling for steroid production. GonadotrtH-induced trans-activation of EGFR in the fish ovary uniquely requires matrix-metalloproteinase-mediated release of EGF. IGF-I and insulin alone can induce fish ovarian steroidogenesis through activation of PI3 kinase and MAP kinase.