Hydrogen peroxide regulates cell adhesion through the redox sensor RPSA
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- 作者：Filipe Vilas-Boasa ; 1 ; favilas-boas@fc.ul.pt" class="auth_mail" title="E-mail the corresponding author ; Ana Bagulhoa ; 1 ; anabagulho@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Rita Tenentea ; 2 ; rita_tenente@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Vitor H. Teixeiraa ; vhteixeira@fc.ul.pt" class="auth_mail" title="E-mail the corresponding author ; Gabriel Martinsb ; c ; gaby@igc.gulbenkian.pt" class="auth_mail" title="E-mail the corresponding author ; Gonç ; alo da Costaa ; gmcosta@fc.ul.pt" class="auth_mail" title="E-mail the corresponding author ; Ana Jeró ; nimoa ; ajeronimosousa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Carlos Cordeiroa ; cacordeiro@fc.ul.pt" class="auth_mail" title="E-mail the corresponding author ; Miguel Machuqueiroa ; mamachuqueiro@fc.ul.pt" class="auth_mail" title="E-mail the corresponding author ; Carla Reala ; csafonso@fc.ul.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：37LRP ; 37 ; kDa laminin receptor precursor ; 67LR ; 67 ; kDa laminin receptor ; CCV ; common cardinal vein ; CTCF ; corrected total cell fluorescence ; ECM ; extracellular matrix ; EGFP ; enhanced green fluorescent protein ; FAK ; focal adhesion kinase ; hpf ; hours post-fertilization ; hpi ; hours post injection ; HUVEC ; human umbilical vein endothelial cells ; IAM ; Iodoacetamide ; IAM-BODIPY ; bodipy-conjugated iodoacetamide ; IRES ; internal ribosome entry site ; ISV ; intersomitic vessels ; M1 ; Manders' overla
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：145-157
- 全文大小：6977 K
文摘
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Ribosomal Protein SA (RPSA) was identified as a target of H2O2.
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RPSA oxidation improves tumor cell adhesion efficiency to laminin in vitro.
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Oxidized RPSA accumulates in clusters that contain specific adhesion molecules.
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RPSA oxidation promotes tumor cell extravasation in zebrafish.
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Upregulation of RPSA might improve tumor cell fitness under oxidative environments.