Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis
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- 作者：Ho Jeon Younga ; b ; Jung Weon Leeb ; c ; jwl@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Sunghoon Kimb ; c
- 关键词：Lysyl-tRNA synthetase ; Laminin receptor ; Cancer metastasis ; Protein-protein interaction ; Anti-cancer drug ; Membrane localization
- 刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：1864
- 期：12
- 页码：1707-1713
- 全文大小：682 K
文摘
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Lysyl-tRNA synthetase facilitates cancer cell migration and invasion.
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Lysyl-tRNA synthetase interacts with the 67 kDa laminin receptor on the plasma membrane.
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Modulation of lysyl-tRNA synthetase-67 kDa laminin receptor interaction suggests a way to control metastasis.