TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway
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- 作者：Lin Zhanga ; b ; 1 ; Wen Qin Chenc ; 1 ; Yi Wei Hub ; d ; Xiao Man Wub ; d ; P. Nieb ; Ming Xian Changb ; mingxianchang@ihb.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Zebrafish ; TBK1 ; TBK1-like transcript ; RIG-I-Like receptors ; IFN ; Innate immune signaling
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：135-143
- 全文大小：2092 K
文摘
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Zebrafish TBK1L contains an incomplete S_TKc domain and lacks UBL_TBK1_like domain.
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Zebrafish TBK1L had little impact on the antiviral state of the cells.
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Zebrafish TBK1L inhibited promoter activities of zebrafish IFN1 and IFN3.
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Zebrafish TBK1L negatively regulated RLRs-MAVS-TBK1 pathway.