The drug candidate, ADX71441, is a novel, potent and selective positive allosteric modulator of the GABAB receptor with a potential for treatment of anxiety, pain and spasticity
文摘
ADX71441 is a novel, potent, selective, orally bioavailable and brain-penetrant GABAB receptor positive allosteric modulator. In rodents ADX71441 exhibits high bioavailability, long half-life and large volume of distribution. In vivo, ADX71441 shows anxiolytic- and antinociceptive-like effects with a consistent in vitro/in vivo correlation.