A novel Nogo-66 receptor antagonist peptide promotes neurite regeneration in vitro
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- 作者：Zhongqing Suna ; 1 ; Xiaoyong Daib ; 1 ; Yu Lia ; Shuwen Jianga ; Guofeng Loub ; Qiaoyu Caob ; Rendong Hua ; Yadong Huangb ; Zhijian Sub ; Meiwan Chenc ; Huanmin Luoa ; Xi Lina ; e ; Jun Sund ; tsunjun@jnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Fei Xiaoa ; e ; xiaofei@jnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nogo-66 receptor ; Antagonist peptide ; Neurite regeneration ; Phage display
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：71
- 期：Complete
- 页码：80-91
- 全文大小：1592 K
文摘
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A novel small NgR1 antagonist peptide NAP2 (MW: 815.98 Da) was identified from a phage display library.
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NAP2 could reduce the Nogo-66-mediated inhibition of neurite outgrowth by blocking the activation of ROCK, CRMP2 and MLC.
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NAP2 binds to NgR1 and the dissociation constant (Kd) was 0.45 μM.