Upregulated expression of Nogo-A and NgR in an experimental model of focal microgyria regulates the migration, proliferation and self-renewal of subventricular zone neural progenitors
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- 作者：Sixun Yua ; 1 ; Haifeng Shua ; 1 ; Tao Yanga ; Haidong Huanga ; Song Lib ; Ziyi Zhaoc ; Yongqin Kuanga ; kuangyongqin@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nogo-A ; Nogo receptor ; Neonatal cortex freeze-lesion ; Neural precursor cells ; Focal cortical dysplasia ; Subventricular zone
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 April 2016
- 年：2016
- 卷：473
- 期：2
- 页码：482-489
- 全文大小：3774 K
文摘
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NFL model is an accurate experimental reproduction of focal microgyria of FCD.
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The increase of the Nogo-A Levels occurs in response to freeze-induced focal lesioning.
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Nogo-A/NgR may play a critical role for in the pathologic progression of FCD.
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Nogo-A is associated with the migration, proliferation and self-renewal of SVZ-NPCs.