Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord
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- 作者：Takaaki Komatsua ; b ; Soh Katsuyamac ; Hiroshi Nagased ; Hirokazu Mizoguchie ; Chikai Sakuradaf ; Minoru Tsuzukif ; Shinobu Sakuradae ; Tsukasa Sakuradaa ; tsukasa@daiichi-cps.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Morphine-3-glucuronide (M3G) ; Dynorphin ; Leucine-enkephalin ; δ2-opioid receptor ; Extracellular signal-regulated kinase (ERK) ; Dorsal spinal cord ; Mice
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：68-74
- 全文大小：709 K
文摘
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Intrathecal injection of M3G evoked nociceptive behaviors in mice.
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Intrathecal injection of M3G evoked activation of spinal ERK in mice.
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M3G-induced nociceptive responses were evoked via spinal δ2-opioid receptors.