The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1
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- 作者：Sí ; lvia Castany1 ; Mireia Carcolé ; 1 ; Sergi Leá ; nez ; Olga Pol ; opol@santpau.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：CoPP ; cobalt protoporphyrin IX ; CORM-2 ; tricarbonyldichlororuthenium(II) dimer ; DOR ; δ-opioid receptor ; DPDPE ; [d-Pen(2) ; d-Pen(5)]-Enkephalin ; HO-1 ; inducible heme oxygenase ; MOR ; μ-opioid receptor ; SnPP ; tin protoporphyrin IX ; STZ ; streptozotocin
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：12 February 2016
- 年：2016
- 卷：614
- 期：Complete
- 页码：49-54
- 全文大小：996 K
文摘
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STZ-induced type 1 diabetic mice develop allodynia and hyperalgesia.
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DPDPE inhibited painful diabetic neuropathy.
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CORM-2 and CoPP treatments enhance the antinociceptive effects of DOR agonists.
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Heme oxygenase 1 participates in the analgesic effects of DPDPE during diabetes.