Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1
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- 作者：Anna Marchenkovaa ; marchenkova.anna@sissa.it" class="auth_mail" title="E-mail the corresponding author ; Arn M.J.M. van den Maagdenbergb ; c ; maagdenberg@lumc.nl" class="auth_mail" title="E-mail the corresponding author ; Andrea Nistria ; nistri@sissa.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：α ; β-meATP ; α ; β-methylene adenosine 5-triphosphate ; AP ; action potential ; BDNF ; brain-derived neurotrophic factor ; BNP ; brain natriuretic peptide ; CGRP ; calcitonin gene-related peptide ; FA ; fast-adaptive ; FHM1 ; familial hemiplegic migraine type-1 ; KI ; knock-in ; MF ; multiple-firing ; NS ; non-spiking ; P2X3R ; P2X3 receptor ; SS ; single-spike ; TG ; trigeminal ganglion ; TRPV1 ; transient receptor potential vanilloid-1 ; WT ; wild type
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：7 September 2016
- 年：2016
- 卷：331
- 期：Complete
- 页码：197-205
- 全文大小：758 K
文摘
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Brain natriuretic peptide inhibits P2X3R-induced excitability of trigeminal neurons.
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BNP-mediated inhibition is lost in trigeminal neurons of a mouse migraine model.
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Lack of BNP-mediated inhibition might confer susceptibility to migraine pain.