Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes

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• 作者：Marko Premzl ; ^{Marko.Premzl@alumni.anu.edu.au" class="auth_mail}
• 关键词：a¯ ; average pairwise identity ; a¯ ; ad ; average absolute deviation for a¯ ; amax ; largest pairwise identity ; amin ; smallest pairwise identity ; C ; C-terminal region ; ECL1-3 ; extracellular regions 1-3 ; H-I-H-VIII ; predicted 伪-helical secondary structure elements ; ICL1-3 ; intracellular regions 1-3 ; MGR ; Mas-related G protein-coupled receptor gene ; N ; N-terminal region
• 刊名：Gene
• 出版年：25 April, 2014
• 年：2014
• 卷：540
• 期：1
• 页码：16-19
• 全文大小：1362 K

文摘

The present study made attempts to update comprehensive eutherian Mas-related G protein-coupled receptor gene data sets, using public eutherian genomic sequence data sets and new genomics and molecular evolution tests. Among 254 potential coding sequences, the most comprehensive gene data set of eutherian Mas-related G protein-coupled receptor genes included 119 complete coding sequences that described eight major gene clusters. The present analysis integrated gene annotations, phylogenetic analysis and protein molecular evolution analysis and first explained differential gene expansion patterns of eutherian Mas-related G protein-coupled receptor genes. The updated classification and nomenclature of eutherian Mas-related G protein-coupled receptor genes were proposed as new framework of future experiments.