Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells

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• 作者：Estelle Louiset^a ; Cé ; line Duparc^a ; Sé ; bastien Lenglet^b ; Celso E. Gomez-Sanchez^c ; Hervé ; Lefebvre^a ; ^d ; ^{herve.lefebvre@chu-rouen.fr}
• 关键词：5-HT ; Cortisol ; Calcium current ; cAMP ; Adrenocortical cells ; Protein kinase A
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：441
• 期：Complete
• 页码：99-107
• 全文大小：1869 K
• 卷排序：441

文摘

Serotonin (5-HT) is produced by mast cells located in zona glomerulosa of human adrenal. 5-HT receptor type 4 (5-HT4) is expressed by cortisol-producing cells positive for 11β-hydroxylase. 5-HT4 receptors are positively coupled to adenylyl cyclase (AC) and cAMP-dependent protein kinase (PKA). Activation of PKA stimulates Ca2+ influx through T- and L-type Ca2+ channels, and cortisol production.