文摘
Reggies (flotillins) and Rab11a regulate trafficking of postsynaptic cargo. Reggies deliver PSD-95, N-cadherin, GluA1 and GluN1 to the postsynaptic spine. Reggie-deficient hippocampal neurons suffer from impaired cargo trafficking. Reggie downregulation impairs spine synapse formation. Surface exposure of GluA1 and GluN1 is reduced which impairs in vitro LTP.