Toll-like receptor-mediated involvement of innate immune cells in asthma disease

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• 作者：Amin Zakeri^a ; ^{Amin.zakeri@stu-mail.um.ac.ir} ; ^{aminzakeri7@gmail.com} ; Fariba Ghiamati Yazdi^b
• 关键词：Allergen ; Asthma ; Innate immune cells ; Toll-like receptors (TLRs)
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3270-3277
• 全文大小：1016 K
• 卷排序：1861

文摘

The innate immunity plays an essential role in mediation of allergic responses. Toll-like receptors (TLRs) have a pivotal role in regulation of innate cells function in the context of asthma disease. Chronic stimulation of TLRs can exacerbate local inflammation via recruitment and activation of innate cells around airways. TLRs have a substantial role in priming innate cells and the regulation of their functions such as cytokine release.