Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy
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- 作者：Ana Agustia ; Marta Llansolab ; Vicente Herná ; ndez-Rabazab ; Andrea Cabrera-Pastorb ; Carmina Montoliua ; Vicente Felipob ; vfelipo@cipf.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：HE ; hepatic encephalopathy ; MHE ; minimal hepatic encephalopathya ; PCS ; portacaval shunt
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：88-93
- 全文大小：379 K
文摘
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GABAergic tone (activation of GABAA receptors) is region-selectively increased in hepatic encephalopathy (HE).
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Increased levels of neurosteroids contribute to increased GABAergic tone.
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Increased GABAergic tone contributes to impaired cognition and motor coordination in HE.
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Reducing GABAergic tone restores cognitive function and motor coordination in HE.
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Modulation of GABAA receptors by neurosteroids is a new therapeutic approach to improve cognitive and motor alterations in HE.