Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action
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- 作者：Federica Marellia ; Silvia Carrab ; Maura Agostinic ; Franco Cotellib ; Robin Peetersd ; Krishna Chatterjeec ; Luca Persania ; e ; luca.persani@unimi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thyroid hormone receptors ; Resistance to thyroid hormone ; Zebrafish ; THRA ; THRB ; Thyroid hormone action
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：424
- 期：Complete
- 页码：102-117
- 全文大小：4036 K
文摘
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We characterize the expression of TRs in zebrafish embryos and adult tissues.
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TR-morphants recapitulate the clinical features of RTHα or RTHβ patients.
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Changes in the expression of deiodinases can explain the high T3/T4 ratio of RTHα.
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Zebrafish and human TRs are functionally interchangeable.
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Mutant hTRs can variably rescue the morphant phenotypes only after high T3 doses.