Neuronal expression of a thyroid hormone receptor α mutation alters mouse behaviour

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• 作者：S. Richard^a ; ^{sabine.richard@ens-lyon.fr} ; N. Aguilera^b ; M. Thé ; venet^c ; ^{mthevenet@olfac.univ-lyon1.fr} ; O. Dkhissi-Benyahya^d ; ^{ouria.benyahya@inserm.fr} ; F. Flamant^a ; ^{frederic.flamant@ens-lyon.fr}
• 关键词：Hypothyroidism ; Brain ; Anxiety ; Conditional gene targeting ; Animal model
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：321
• 期：Complete
• 页码：18-27
• 全文大小：1830 K
• 卷排序：321

文摘

The role of central thyroid hormone receptors in emotional behaviour was assessed. A neuron-specific TRα mutation induced anxiety-like behaviour in mice. Stressful housing conditions potentiated the effects of the TRα mutation. We conclude that neuronal TRα signalling influences adult anxiety behaviour. Neuronal TRα thus constitutes a functional link between hypothyroidism and anxiety.