PSD-95 regulates synaptic kainate receptors at mouse hippocampal mossy fiber-CA3 synapses
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- 作者：Etsuko Suzukia ; b ; Haruyuki Kamiyaa ; kamiya@med.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPARs ; AMPA receptors ; fEPSPs ; field EPSPs ; KARs ; kainate receptors ; mEPSCKA ; kainate receptor-mediated miniature EPSC ; PSD ; postsynaptic density
- 刊名：Neuroscience Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：14-19
- 全文大小：756 K
文摘
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Synaptic scaffolding mechanism of kainate receptors was investigated.
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Roles of PSD-95 on synaptic kainate receptors were tested using the knockout mice.
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Kainate receptors at mossy fiber synapse are reduced in PSD-95 knockout mice.
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PSD-95 serve as a scaffold of kainate receptors at hippocampal mossy fiber synapse.