Novel Functional Properties of Drosophila CNS Glutamate Receptors

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• 作者：Yan Li¹ ; ³ ; Poorva Dharkar² ; ³ ; Tae-Hee Han¹ ; Mihaela Serpe¹ ; Chi-Hon Lee¹ ; ^{leechih@mail.nih.gov} ; Mark L. Mayer² ; ⁴ ; ^{mayerm@mail.nih.gov}
• 关键词：Drosophila ; glutamate receptors ; NMDA ; AP5 ; crystal structures
• 刊名：Neuron
• 出版年：2016
• 出版时间：7 December 2016
• 年：2016
• 卷：92
• 期：5
• 页码：1036-1048
• 全文大小：3747 K
• 卷排序：92

文摘

Insects have an expanded kainate-type iGluR repertoire among three classical iGluRs Insect kainate and “AMPA” receptors form homomeric Ca+-permeable channels Insect iGluRs have different agonist/antagonist selectivity from vertebrate’s The cation/anion-modulation is decoupled or eliminated in insect kainate receptors