Netrin-1: A regulator of cancer cell motility?

详细信息    查看全文

• 作者：Irene Ylivinkka^a ; ^b ; Jorma Keski-Oja^a ; ^b ; Marko Hyytiä ; inen ; Ph.D.^a ; ^{marko.hyytiainen@helsinki.fi" class="auth_mail" title="E-mail the corresponding author}
• 关键词：C. Elegans ; Caernohabtidis Elegans ; DCC ; deleted in colorectal cancer ; D. Melanogaster ; Drosophila Melanogaster ; DSCAM ; Down syndrome cell adhesion molecule PMEC primary midgut epithelial cell ; UNC-6 ; uncoordinated-6 ; UNC5 ; uncoordinated5 ; YAP ; yes associated protein
• 刊名：European Journal of Cell Biology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：95
• 期：11
• 页码：513-520
• 全文大小：911 K

文摘

Netrins form a family of secreted and membrane-associated proteins, netrin-1 being the prototype and most investigated member of the family. The major physiological functions of netrin-1 lie in the regulation of axonal development as well as morphogenesis of different branched organs, by promoting the polarity of migratory/invasive front of the cell. On the other hand, netrin-1 acts as a factor preventing cell apoptosis. These events are mediated via a range of different receptors, including UNC5 and DCC-families. Cancer cells often employ developmental pathways to gain survival and motility advantage. Within recent years, there has been increasing number of observations of upregulation of netrin-1 expression in different forms of cancer, and the increased expression of netrin-1 has been linked to its functions as a survival and invasion promoting factor. We review here recent advances in the netrin-1 related developmental processes that may be of special interest in tumor biology, in addition to the known functions of netrin-1 in tumor biology with special focus on cancer cell migration.