Thyroid disruption in male goldfish (Carassius auratus) exposed to leachate from a municipal waste treatment plant: Assessment combining chemical analysis and in vivo bioassay
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- 作者：Yufeng Gong ; Hua Tian ; Yifei Dong ; Xiaona Zhang ; Jun Wang ; Wei Wang ; weiwang@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Shaoguo Ru ; rusg@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：TDCs ; thyroid-disrupting chemicals ; HPT ; hypothalamus&ndash ; pituitary&ndash ; thyroid ; TH ; thyroid hormone ; TSH ; thyroid-stimulating hormone ; T4 ; 3 ; 3&prime ; 5 ; 5&prime ; -l-thyroxine ; T3 ; 3 ; 3&prime ; 5-triiodo-l-thyronine ; D1 ; type I iodothyronine deiodinases ; D2 ; type II iodothyronine deiodinases ; D3 ; type III iodothyronine deiodinases ; TRs ; thyroid receptors ; 4-t-OP ; 4-t-octylphenol ; BPA ; bisphenol A ; TBBPA ; tetrabromobisphenol A ; DnBP ; di-n-butyl phthalate ; DnBP ; di-n-butyl phthalate ; DNOP ; di-n-oc
- 刊名：Science of the Total Environment
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：554-555
- 期：Complete
- 页码：64-72
- 全文大小：798 K
文摘
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The impacts of leachate on thyroid cascade of aquatic organisms are not known.
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BPA, 4-t-OP, DnBP, DEHP, and DNOP were detected in refuse leachate.
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leachate exposure for 21 days led to thyroid disruptions in male goldfish.
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Only bioassays could provide a valid approach to detect toxicity of complex mixtures.